Current projects in the lab are associated with an NIH Pathway to Indepenence award titled: Role of novel CNS subcircuits in cue-induced drug relapse.
To examine whether subregions within orbitofrontal-basolateral amygdala circuits may differentially affect relapse to cue-induced cocaine-seeking behavior, we will:
Map subregions of the orbitofrontal cortex (ventro, lateral, dorsolateral) that send monosynaptic projections to subregions of the basolateral amygdala (rostral, caudal).
Assess cue-induced neural activation in the above-mentioned subregions.
Use circuit-specific viral and optogenetic manipulations to potentially alter reinstatement of drug-seeking behavior.